|
KMID : 0371320060700060462
|
|
Journal of the Korean Surgical Society
2006 Volume.70 No. 6 p.462 ~ p.469
|
|
|
|
|
서현일/Seo HI
전우규/강진호/임시영/이승세/손병호/류창학/신준호/김흥대/한원곤/오태윤/우희연/박효순/Jeon WK/Kang JH/Lim SY/Lee SS/Sohn BH/Ryu CH/Shin JH/Kim HD/Han WK/Oh TY/Woo HY/Park HS
|
|
|
Abstract
|
|
|
Purpose: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-α following the abdominal surgery.
Methods: 46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-α and CRP were also measured. The clinical course was followed and compared in both groups.
Results: The colostrum group showed significantly lower level of endotoxin and TNF-α compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance.
Conclusion: Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-α. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum. (J Korean Surg Soc 2006;70:462-469)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|